publications
Full list of publications by Maureen Su Lab​
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Lechner MG, Zhou Z, Hoang AT, Huang N, Ortega J, Scott LN, Chen HC, Patel AY, Yakhshi-Tafti R, Kim K, Hugo W, Famini P, Drakaki A, Ribas A, Angell TE, Su MA. Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis. Sci Transl Med. 2023 May 17;15(696):eadg0675. doi: 10.1126/scitranslmed.adg0675. Epub 2023 May 17. PMID: 37196065; PMCID: PMC10227862.
Ding L, Sun L, Bu MT, Zhang Y, Scott LN, Prins RM, Su MA, Lechner MG, Hugo W. Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors. Front Immunol. 2023 Jun 26;14:1176994. doi: 10.3389/fimmu.2023.1176994. PMID: 37435085; PMCID: PMC10330698.
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Cheng MI, Li JH, Riggan L, Chen B, Tafti RY, Chin S, Ma F, Pellegrini M, Hrncir H, Arnold AP, O'Sullivan TE, Su MA. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nat Immunol. 2023 Mar 16. doi: 10.1038/s41590-023-01463-8. Epub ahead of print. PMID: 36928413.
Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis. J Endocr Soc. 2023 Feb 6;7(4):bvad012. doi: 10.1210/jendso/bvad012. PMID: 36860908; PMCID: PMC9969737.
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Valenzise M, Foti Randazzese S, Toscano F, Lombardo F, Salzano G, Pajno C, Wasniewska M, Cascio A, Su MA. Mild COVID-19 in an APECED Patient with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and High Titer of Type 1 IFN-Abs: A Case Report. Pathogens. 2023 Mar 2;12(3):403. doi: 10.3390/pathogens12030403. PMID: 36986325.
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Mandy I. Cheng, Luke Riggan, Joey H. Li, Rana Yakhshi Tafti, ScottChin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O’Sullivan, Maureen A. Su. Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX. Preprint at: https://www.biorxiv.org/content/10.1101/2022.04.21.489076v2
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Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors. bioRxiv 2022.12.08.519660; doi: https://doi.org/10.1101/2022.12.08.519660
Lechner, M. G., Zhou, Z., Hoang, A. T., Huang, N., Ortega, J., Scott, L. N., Chen, H.-C., Patel, A. Y., Yakhshi-Tafti, R., Kim, K., Hugo, W., Famini, P., Drakaki, A., Ribas, A., Angell, T. E. & Maureen A. Su. Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis. bioRxiv, 2022.2012.2018.517398, doi:10.1101/2022.12.18.517398 (2022).
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Melissa G. Lechner, Mandy I. Cheng, Anushi Y. Patel, Aline T. Hoang, Natalie Yakobian, Michael Astourian, Marissa S. Pioso, Eduardo D. Rodriguez, Ethan C. McCarthy, Willy Hugo, Trevor E. Angell, Alexandra Drakaki, Antoni Ribas, Maureen A. Su Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy The Journal of Immunology July 11, 2022, ji2200244; DOI: 10.4049/jimmunol.2200244
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Wang Y, Guo L, Yin X, McCarthy EC, Cheng MI, Hoang AT, Chen HC, Patel AY, Allard Trout D, Xu E, Yakobian N, Hugo W, Howard JF Jr, Sheu KM, Hoffmann A, Lechner MG, Su MA. Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2114406119. doi: 10.1073/pnas.2114406119. PMID: 35058362.
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Dasgupta A, Tsay E, Federman N, Lechner MG, Su MA. Polyendocrine Autoimmunity and Diabetic Ketoacidosis Following Anti-PD-1 and Interferon α. Pediatrics. 2022 Apr 1;149(4):e2021053363. doi: 10.1542/peds.2021-053363. PMID: 35274131; PMCID: PMC9804498.
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Wilkinson NM, Chen HC, Lechner MG, Su MA. Sex Differences in Immunity. Annu Rev Immunol. 2022 Jan 5. doi: 10.1146/annurev-immunol-101320-125133. Epub ahead of print. PMID: 34985929.
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Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Mar;591(7849):300-305. doi: 10.1038/s41586-021-03231-w. Epub 2021 Jan 27. Nature. 2021 Apr;592(7856):E29. PMID: 33505023; PMCID: PMC8080937.
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Kathuria-Prakash N, Mosaferi T, Xie M, Antrim L, Angell TE, In GK, Su MA, Lechner MG. COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study. Endocr Pract. 2021 Feb;27(2):90-94. doi: 10.1016/j.eprac.2020.12.013. Epub 2021 Jan 4. PMID: 33551317; PMCID: PMC7831810.
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Wolbert J, Cheng MI, Meyer zu Horste G, Su MA. Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies. JCI Insight. 2020 Feb 13;5(3):e132411. doi: 10.1172/jci.insight.132411.
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Hwang BJ, Zhang Y, Brozowski JM, Liu Z, Burette S, Lough K, Smith CC, Shan Y, Chen J, Li N, Williams S, Su M, Googe P, Thomas NE, Liu Z. The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression.
Oncogene. 2019 Dec;38(50):7491-7503. doi: 10.1038/s41388-019-0961-9. Epub 2019 Aug 21.
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Su MA, Anderson MS. Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy. Cancer Immunol Res. June 2019; 7(6):854-859.
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Brown MA, Su MA. An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses. J Immunol. April 2019; 202(7):1927-1933.
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Liu C, He H, Li X, Su MA, Cao Y. Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy. Br J Cancer. February 2019; 20(3):346-355.​
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Allard DE, Wang Y, Li JJ, Conley B, Xu EW, Sailer D, Kimpston C, Notini R, Smith CJ, Koseoglu E, Starmer J, Zeng XL, Howard JF Jr, Hoke A, Scherer SS, Su MA. Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. J Clin Invest. October 2018; 128(10):4727-4741.
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Zhang Y, Hwang BJ, Liu Z, Li N, Lough K, Williams SE, Chen J, Burette SW, Diaz LA, Su MA, Xiao S, Liu Z. BP180 dysfunction triggers spontaneous skin inflammation in mice. Proc Natl Acad Sci U S A. June 2018; 115(25):6434-6439.
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Collin-Jamal Smith, Denise E. Allard, Yan Wang, James F. Howard Jr., Stephanie A. Montgomery and Maureen A. Su. IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration. J Immunol. March 2018; 200(5):1580-1592.
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Pearl Bakhru, Meng-Lei Zhu, Hsing-Hui Wang, Lee K. Hong, Imran Khan, Maria Mouchess, Ajay S. Gulati, Joshua Starmer, Yafei Hou, David Sailer, Sandra Lee, Fengmin Zhao, John M. Kirkwood, Stergios Moschos, Lawrence Fong, Mark S. Anderson, Maureen A. Su. Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity. JCI Insight. 2017; 2(18):e93265.
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Zhu, Menglei*, Bakhru, Pearl*, Martin, Aaron, Conley, Bridget, Free, Meghan, Nelson, Jennifer, Starmer, Joshua, Wilson, Elizabeth M., Su, Maureen A., Sex bias in CNS autoimmune disease mediated by androgen control of Autoimmune Regulator. Nature Communications volume 7, Article number: 11350 (2016).
*Shared authorship
Thrasher, Bradly; Hong, Lee Kyung; Whitmire, Jason; and Su, Maureen A., Epigenetic dysfunction in Turner Syndrome immune cells. Curr Allergy Asthma Rep. May 2016; 16(5):36.
Anderson, Mark S. and Su, Maureen A., Aire expands: new roles in immune tolerance. Nat Rev Immunol. April 2016; 16(4):247-58.
Bakhru, Pearl, and Su, Maureen A. Estrogen turns down the ‘Aire.’ J Clin Invest., 2016 Apr 1; 126(4): 1239–1241.
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Cook KD, Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity. October 20 2015; 43(4):703-14.
*Shared Authorship
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Su MA, Anderson MS. Breaking through the central tolerance ceiling to unleash anticancer immune responses. Oncoimmunology. August 3 2014;3(8).
Whitfield-Larry F, Felton J, Buse J, Su MA. Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients. Clin Immunol. July 2014;153(1):156-64.
Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med. May 5 2014;211(5):761-8
Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immune tolerance. Nat Immunol. March 2014;15(3):258-65.
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Sarantopoulos S, Su MA. BAFF-ling autoantibodies. J Clin Invest. December 2013;123(12):5006-8.
Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK. Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. J Immunol. December 1 2013;191(11):5655-68.
Free ME, Bunch DO, McGregor JA, Jones BE, Berg EA, Hogan SL, Hu Y, Preston GA, Jennette JC, Falk RJ, Su MA. Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. Arthritis Rheum. July 2013; 65(7):1922-33.
Zeng Xiaopei L., Nagavalli Anil, Smith Colin-Jamal, Howard James F., Su Maureen A. Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by aire deficiency. Journal of Immunology. April 15 2013; 190(8): 3895-3904.
Free Meghan E., Bunch Donna O., McGregor JulieAnne, Britta Jones E., Berg Elisabeth A., Hogan Susan L., Hu Yichun, Preston Gloria A., Jennette J. C., Falk Ronald J., Su Maureen A. ANCA-associated vasculitis patients have defective Treg function exacerbated by presence of a suppression-resistant effector population. Arthritis & Rheumatism. April 1 2013.
Zhu Meng-Lei, Navagalli Anil, Su Maureen A. Aire deficiency promotes TRP-1 specific immune rejection of melanoma. Cancer Research. April 1 2013; 73(7): 2104-2116.
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Su Maureen A.*, Davini Dan, Giang Karen, Fan Una, DeVoss Jason J., Johannes Kellsey P.A., Shum Anthony K., Valenzise Mariella, Veloni Antonella, Bour-Jordan Helene, and Anderson Mark S.* Defective Aire-Dependent Central Tolerance to P0 Predisposes to Autoimmune Peripheral Neuropathy. Journal of Immunology. May 2012; 188: 4906-4912.
*Shared senior authorship.
**Selected for “In This Issue” article, which highlights articles among top 10% of journal articles
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Wang Yunqi, Su Maureen A, and Wan Yisong Y. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity. Sep 2011; 35(3):337-48.
Anderson Mark S and Su Maureen A. Aire and T cell Development. Current Opinions in Immunology, Apr 2011; 23(2):198-206.
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Su Maureen A and Anderson Mark S. Monogenic Autoimmune Diseases: Insights into the Immune System. Pediatric Research, 2009 May; 65(5 Pt 2):20R-25R.
Su Maureen A, Stenerson Matthew, Liu Weihong, Putnam Amy, Conte Felix, Bluestone Jeffrey A, and Anderson Mark S. The Role of X-linked FOXP3 in the Autoimmune Susceptibility of Turner Syndrome Patients. Clinical Immunology, Apr 2009, 131(1):139-44.
Louvet Cedric, Kabre Beniwende, Davini Dan, Martinier Nicolas, Su Maureen A, Devoss Jason, Rosenthal Wendy, Anderson Mark S., Bour-Jordan Helene, and Bluestone Jeffrey A. A novel myelin P0-specific T cell receptor transgenic mouse develops fulminant autoimmune peripheral neuropathy. Journal of Experimental Medicine, Mar 16 2009, 206(3): 507-14.
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Gardner James M, Devoss Jason J, Friedman Rachel S, Wong David J, Tan Ying X, Zhou Xuyu, Johannes Kellsey P, Su Maureen A, Chang Howard Y, Krummel Matthew F, Anderson Mark S. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science, Aug 8, 2008;321(5890):843-7.
Su Maureen A, Giang Karen, Zumer Kristina, Jiang Huimin, Oven Irena, Rinn John L, Devoss Jason J, Johannes Kellsey P, Lu Wen, Gardner James, Chang Angela, Bubulya Paula, Chang Howard Y, Peterlin B Matija, Anderson Mark S. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. Journal of Clinical Investigation, May, 2008; 118(5):1712-26.
*Featured as Cover Article “Walking on Aire.”
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Zhang Li, Barker Jennifer M, Babu S, Su Maureen, Stenerson Matthew, Cheng Mickie, Shum Anthony, Zamir Ehud, Badolato Raffaele, Law Adam, Eisenbarth George S, Anderson Mark S. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clinical Immunology, Nov, 2007; 125(2):131-7.
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Sipe Walter E, Su Maureen, Posselt Andrew, Kim Grace E, Quiros Jose A, Rosenthal Philip. Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves’ disease. Pediatric Transplantation, Jun 2006;10(4):525-8.
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Su Maureen A, Anderson Mark S. Aire: an update. Current Opinions in Immunology, Dec 2004;16(6):746-52.